assessing the effect of intra-paragigantocellularis lateralis injection of 17β- estradiol on the acute and persistent pain in the male rat
نویسندگان
چکیده
introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and gabaa receptors. beside its autonomic functions, paragigantocellularis lateralis (lpgi) nucleus is also involved in pain modulation. the aim of the current study was to investigate the role of the intracellular estrogenic receptors in the pain modulation by the lpgi nucleus of male rats. methods: in this study, male wistar rats in the range of 200-270 gr were used. in order to study the effect of intra- lpgi microinjection of 17β-estradiol on both acute and persistent pain modulation, cannulation of lpgi nucleus was performed. at first, drugs were injected and 15 minutes later 50 μl of 4% formalin was injected into the rat's hind paw. then formalin-induced flexing and licking behaviours were recorded for 60 min. results: the results of current study showed that intra-lpgi injection of 17β-estradiol attenuated the flexing and the licking behaviours both in the first phase (p<0.01) and in the second phase (p<0.001) of formalin test. the estrogen receptor antagonist (ici182,780) prevented 17β-estradiol-induced analgesic effect but could not reverse this effect to the control condition, and it had significant difference with the control group, yet. conclusion: it may be concluded some part of the analgesic effect of 17β-estradiol in the lpgi nucleus on the formalin-induced inflammatory pain is probably mediated by estrogenic receptors.
منابع مشابه
Assessing the effect of intra-paragigantocellularis lateralis injection of 17β- estradiol on the acute and persistent pain in the male rat
Introduction: 17β-estradiol modulates nociception by binding to estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. Beside its autonomic functions, paragigantocellularis lateralis (LPGi) nucleus is also involved in pain modulation. The aim of the current study was to investigate the role of the intracellular estrogen...
متن کاملThe role of GABAA receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat
Introduction: 17&beta-Estradiol modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. In addition to its autonomic functions, paragigantocellularis lateralis (LPGi) is involved in the pain modulation, too. The aim of the current study was to investigate the involvement of the membra...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولthe role of gabaa receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat
introduction: 17&beta-estradiol; modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and gabaa receptors. in addition to its autonomic functions, paragigantocellularis lateralis (lpgi) is involved in the pain modulation, too. the aim of the current study was to investigate the involvement of the membr...
متن کاملThe role of GABAA receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat
Introduction: 17β-Estradiol modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABAA receptors. In addition to its autonomic functions, paragigantocellularis lateralis (LPGi) is involved in the pain modulation, too. The aim of the current study was to investigate the involvement of the membrane-b...
متن کاملthe effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۱۸، شماره ۴، صفحات ۴۵۵-۴۶۵
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023